Journal Reviews

Allergy journal cover image

Allergic rhinitis, the usual suspects

27 February 2020 | | Rhinology / Sinus | allergic rhinitis, cysteinyl leukotriene, eosinophil, group 2 innate lymphoid cells, prostaglandin D2

Allergic rhinitis (AR) is characterised by allergen binding to IgE on mast cells and basophils and subsequent histamine, prostaglandine D2 (PGD2) and cysteinyl leukotrienes (cysLTs) release causing early-phase response. This is followed by late-phase response mediated by eosinophils. Other cells,...

Prostaglandin versus leukotriene receptor-antagonists in treatment of seasonal allergic rhinitis RCT phase II

1 January 2018 | | Bayesian posterior probability, allergic rhinitis, leukotriene receptor antagonist, mast cell degranulation, prostaglandin D2 receptor 1 antagonist

Seasonal allergic rhinitis is very common. Failure to control the disease with mono-therapy leads to dual therapy treatment with less compliance and reduced quality of life. A prostaglandin receptor antagonist (ONO-4053) showed some efficacy in controlling allergic rhinitis in animal...